|
KMID : 1039120220110010121
|
|
Clinical and Experimental Vaccine Research
2022 Volume.11 No. 1 p.121 ~ p.124
|
|
|
Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
|
|
Klingel Hanna
Lauen Maike
Kruttgen Alexander
Imohl Matthias
Kleines Michael
|
|
|
Abstract
|
|
|
|
Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.
|
|
|
KEYWORD
|
|
|
Adverse reactions, Antibody response, SARS-CoV-2, T-cell response, Vaccine mRNA-1273
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|